Excipients in pharmaceutical preparations are additives to the main drug. They are not directly involved in the therapeutic action of the drug, but play a vital role in the shaping, stabilization and release of the drug.
Anhydrous calcium phosphate excipient is an excipient with anhydrous calcium phosphate as the main ingredient.It is a commonly used excipient in the production of food, pharmaceuticals, and toothpaste.
Basic information of Anhydrous Calcium Hydrogen Phosphate
Anhydrous Calcium Hydrogen Phosphate is also called as Dibasic Calcium Phosphate Anhydrous , shorten as DCPA. Its chemical formula is CaHPO4 and molecular weight of 136.06. Its CAS number is 7757-93-9 and its purity is usually 98.0-105.0%. Anhydrous Calcium Hydrogen Phosphate is a white amorphous powder, soluble in dilute hydrochloric acid, nitric acid, phosphoric acid, acetic acid and sulfurous acid, slightly soluble in water, insoluble in ethanol.
Anhydrous Calcium Hydrogen Phosphate as excipient has the following characteristics and applications:
Compressibility and Pliability:
Due to its compressibility and suppleness, anhydrous calcium hydrogen phosphate is widely used in the preparation of excipients for tablets and capsules, which can improve the flowability and molding of drugs.
Stability:
Anhydrous Calcium Hydrogen Phosphate is stable at room temperature and will not be hydrated to dihydrate under high humidity conditions. It is usually considered non-toxic and non-irritating, so it is widely used in oral drug preparations, food and toothpaste.
Application areas:
- Anhydrous calcium phosphate is commonly used as excipient in the preparation of vitamin and mineral drugs, such as calcium tablets and tablets as additives for drugs, used to supplement phosphorus and calcium.
- It is also used in food and toothpaste. It is also used in foods and toothpastes to provide essential minerals and improve product texture.
Use in pharmaceutical preparations
- Filler: Due to its good compressibility and flowability, anhydrous calcium phosphate is commonly used as a filler in pharmaceutical preparations, especially in oral drug preparations.
- Direct tabletting: Anhydrous Calcium Hydrogen Phosphate in coarse granular form can be used directly for tabletting without further processing.
- Wet or dry granulation: crushed anhydrous calcium phosphate can be used for wet or dry granulation.
Role in toothpaste
Improve the stability of toothpaste:
- Its coarse particles have good compressibility and flowability, making it suitable for application as a filler in toothpaste.
- Due to its deformation mechanism of brittle fracture, it does not swell due to moisture absorption when used at higher pressures, thus reducing the likelihood of the paste separating.
- Anhydrous Calcium Hydrogen Phosphate is chemically stable and ensures that the physical and chemical properties of the toothpaste remain unchanged during storage, thus extending the service life of the toothpaste.
Friction agent
- Removes and disperses tartar and calculus from the tooth surface by friction.
- Good abrasive effect, less damage to the tooth surface.
- High glossy appearance, good polishability on tooth surface, can be used in high-grade whitening toothpaste.
- Moderate hardness, good crystal shape, less damage to tooth surface, especially suitable for children and people who already have root exposure problems.
Advantgages:
- Low irritation: The pH value is close to neutral, less irritation to oral mucosa.
- Good dispersibility: High dispersibility, more adaptable with fluoride, suitable with anti-cavity toothpaste.
Conclusion
Anhydrous Calcium Hydrogen Phosphate can be used as a good excipient due to its unique physical and chemical properties. It has good compressibility and flowability which makes it suitable for use as filler in pharmaceutical formulations. Anhydrous Calcium Hydrogen Phosphate is non-hygroscopic, stable at room temperature and does not hydrate to dihydrate, which makes it stable under high humidity conditions and has a high safety profile. It is usually considered non-toxic and non-irritating. In addition, different particle size grades of anhydrous calcium phosphate can be used in different preparation processes; crushed particles can be used in wet or dry granulation, while coarser particles can be used in direct tabletting finally. For the above reasons, it is widely used as excipient in food and medicine.
In toothpaste, it is not only used as excipient, it is also used as filler and friction agent. It has the advantages of little stimulation to the oral cavity, good abrasive effect, moderate hardness, high diffusivity, etc. It is suitable for high-grade whitening toothpaste as well as fluoride toothpaste, and is especially suitable for children and people with pressure root exposure problems.
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